Ion Channel & Transporter Screening
Label-Free Compound Screening
Find solutions to screen your compounds of interest targeting ion channels and transporters using our Label-free Ion Channel Reader (ICR)
Ion channels & transporters are important therapeutic targets in the drug development pipeline and drug safety evaluation. These drug targets are critically important for a range of physiological conditions and disorders.
Ion channels are key drug targets, modulated by neurotoxins and bioactive compounds with therapeutic potential. However, hERG channel blockade can cause fatal arrhythmias like Torsades de Pointes (TdP), leading to drug withdrawals.
Our Testing Services:
✔ Manual Patch Clamp & High-Throughput ICR – Gold-standard electrophysiology
✔ Custom Assays & Safety Screening – Early-phase toxicity & efficacy testing
✔ Expert Support – Assay selection, execution & data interpretation
Our Scientists help you to determine the right assay format and platform for your specific requirements and also help you to run your experiments safely and fast through your data interpretation. We help you to find solutions for your ion channel/transporter research that meet your needs and also provide comprehensive in vitro assessment for compound safety profiles in the early-phase discovery process.
Ensure precision in your ion channel research. Contact us today!
Cell lines expressing various ion channel targets are available for contract electrophysiological assays. In addition, Aurora carries isolated cardiomyocytes from various species, Xenopus oocyte, as well as human induced pluripotent stem cell – derived cardiomyocytes (hiPSC-CM) for functional characterization of ion channels。
Ion Channel Targets
| Cardiac | Others |
| hERG | TRPV1 |
| Nav1.5 | Nav1.6 |
| Kv1.5 | Nav1.7 |
| Kv4.3 | Kv1.2 |
| KCNQ1/KCNE1 | Kv2.1 |
| HCN4 | Kv3.1 |
| Kir2.1 | Kv3.2 |
| Kir3.1/Kir3.4 | Kv4.2 |
| Cav1.2 | Cav3.3 |
| HCN2 | |
| Nav1.4 | |
| Kv1.3 |
Aurora’s proprietary Ion Channel Readers measure ion channel and transporter activity by detecting ion movements across membrane proteins through quantifying intracellular and extracellular ion concentrations of interest in a high throughput and cell-based assay format. This is a technique that is independent of, and complementary to methods that rely on voltage manipulation. Since ion flux is a direct measure of channel activity, such assays are robust and less sensitive to disturbances. Data generated by the ICR Series are very consistent and predictive of compound potency.
Need help with your in vitro assessment for compound safety profiles?
Let us help you with our cost-effective, high-quality, reproducible data.
