Day2

8:00 AM – 8:30 AM – Registration

8:20 AM – 8: 25AM – Welcome & Opening Remarks: Aurora Biomed Inc

Keynote Presentation

8:25 AM – 9:05AM – Alfred George

Chair, Department of Pharmacology, Northwestern University – “Functional Annotation of Human Ion Channel Variants”

PM Session: Applications of NGS

9:05 AM – 9:10AM Chair: Alfred George

Department of Pharmacology, Northwestern University

9:10 AM – 9:30 AM – Ashleen Shadeo

Sector Manager, Health Genome BC – “Implementing Genomics in the Health Care System in Canada”

9:30 AM – 9:50 AM – Tao Chen

CEO, Paragon Genomics – “A Novel Amplicon-based NGS Target Enrichment Technology for Liquid Biopsies in Oncology”

9:50 AM – 10:10 AM – Amit Mahipal

Associate Professor, Mayo Clinic NGS – “How Molecular Testing has Changed Therapy Decisions in Colorectal Cancer”

10:10 AM – 10:30 AM – Gourab Bhattacharjee

Marketing Programs Manager, Oncology, Illumina – Immuno-Oncology Research Enabled Through Applied Advanced Genomic Techniques

10:30 AM – 10:50 AM – Coffee Break & Posters

Technologies and Technical Session

10:50 AM – 10:55 AM – Chair: Ali Yehia

VP IonFlux Product and Director of BioFlux Business Marketing, Fluxion

10:55 AM – 11:15 AM – Ali Yehia

VP IonFlux Product and Director of BioFlux Business Marketing, Fluxion – “Application of microfluidics to ion channel drug discovery and liquid biopsies for precise cancer diagnosis”

11:15 AM – 11:35 PM – Ander Lindqvist

Application Scientist, Sophion – “The effect of temperature on hERG channel pharmacology measured using the Qube automated patch clamp system”

11:35 AM – 11:55 PM – Daniel Beacham

Senior Staff Scientist, Molecular Probes Labelling and Detection, Thermo Fisher Scientific – “CultureOne Media Supplement Accelerates Functional NSC Maturation as Revealed with Improved Imaging Solutions”

11:55 PM – 12:20PM – Aneesh Karatt Vellatt

Senior Research Scientist, Iontas Ltd.- “KnotBodies: creating Ion channel blocking antibody by fusing knottins into peripheral CDR loops”

12:20 PM – 1:20 PM – Lunch

1:20 PM – 2:30 PM – PM Session Panel Discussion

– Break into Parallel Sessions-

-Precision Medicine Session-

PM Session: Liquid Biopsy and Molecular Diagnostics

2:35 PM – 2:40 PM – Chair: David Weitz

Professor, Mallinckrodt Professor of Physics and Applied Physics, Harvard University

2:40 PM – 3:00 PM – David Weitz

Professor, Mallinckrodt Professor of Physics and Applied Physics, Harvard University – “Droplet microfluidics for single cell studies”

3:00 PM – 3:20 PM – Werner Struss

Senior Research Scientist, Vancouver Prostate Centre – “Treatment outcomes and tumor loss-of -heterozygosity in germline DNA repair deficient prostate cancer”

3:20 PM – 3:40 PM – Miguel Alcaide

Research Associate, Simon Fraser University – “Novel ultrasensitive methods for the detection and quantification of tumor-derived genetic aberrations in the “liquid biopsy” era”

3:40 PM – 4:00 PM – Paul Li

Professor, Department of Molecular Biology and Biochemistry Simon Fraser University – “Microfluidic Technology for Liquid Biopsy in Precision Medicine”

4:00 PM – 4:25 PM – Coffee Break & Posters

PM Session: Lab-on-a-Chip and Biotechnology

4:25 PM – 4:30 PM – Chair: Paul August

VP, Icagen

4:30 PM – 4:50 PM – Paul August

VP , Icagen – “Patient derived stem cells as a strategy for the in vitro evaluation of muscular dystrophy therapies”

4:50 PM – 5:10 PM – Anthony Bahinski

Global Head, Safety Pharmacology, GlaxoSmithKline – “Human Organs on Chips: Opportunities and Challenges for Personalized Drug Development”

5:10 PM – 5:30 PM – Justin Ichida

Principal Investigator, University of Southern California Stem Cell – “Identification of therapeutic targets for ALS using chemical and genetic screens on patient-derived neural cultures”

– End of Parallel Session-

6:10 PM – 9:30 PM – Boat Cruise Banquet

-Ion Channel Session-

IC Session: Ion Channels and Transporters in Neuroscience

2:40 PM – 2:45 PM – Chair: Dandan Sun

Professor of Neurology, University of Pittsburgh

2:45 PM – 3:05 PM – Shan Ping Yu

Professor of Anesthesiology, Emory University School of Medicine – “Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice”

3:05 PM – 3:25 PM – Kris Kahle

Professor of Neurosurgery, Yale School of Medicine – “NKCC1-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus”

3:25 PM – 3:45 PM – Melanie A Woodin

Associate Professor, University of Toronto – “Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition”

3:45 PM – 4:05 PM – Sun Dandan

Professor of Neurology, University of Pittsburgh – “WNK-SPAK/OSR1 Signaling Pathway as a Novel Target for Ischemic Stroke Therapy ”

4:05 PM – 4:25 PM – Giuseppe Pignataro

Associate Professor in Pharmacology, Department of Neuroscience, School of Medicine, University of Naples – “Na+/Ca2+ exchangers in neurological diseases”

4:25 PM – 4:45 PM – Coffee Break & Posters

4:45 PM – 5:05 PM – Maria Barthmes

Application Specialist, Nanion – “Targeting transporters with HTS electrophysiology: The glutamate transporter EAAT3 on the SURFE2R 96SE”

5:05PM – 5:25 PM – Matt Fox

CEO, Pairnomix – “Comprehensive High Throughput Drug Screening in a Cellular Model of SCN8A Epilepsy ”

– End of Parallel Session-

6:10 PM – 9:30 PM – Boat Cruise Banquet

Day3

7:55 AM – 8:25 AM – Registration

IC Session: Ion channels as Disease Targets

8:20 AM – 8:30 AM – Opening Remarks

Chair: Yelena Bisharyan

Director of External Alliances , Tetragenetics

8:30 AM – 9:00 AM – Ted Clark

CSO Tetragenetics, Cornell University – “Antibodies Against Difficult to Express Ion Channel Targets”

9:00 AM – 9:20 AM – Robert Brenner

Associate Professor, University of Texas Health Science Center at San Antonio – “Membrane-Permeant SK Potassium Channel Antagonists are Potent Bronchorelaxants”

9:20 AM – 9:40 AM – Heike Wulff

Full Professor, Department of Pharmacology, University of California Davis – “Kv1.3 as a target

for inhibiting detrimental M1 microglia functions in ischemic stroke, Alzheimer’s and Parkinson’s disease”

9:40 AM – 10:00 AM – Brandon Brown

Associate Professor, University of Texas Health Science Center at San Antonio – “Membrane Permeant SK Potassium Channel Antagonists are Potent Bronchorelaxants”

10:00 AM – 10:35 AM – Coffee Break & Posters

IC Session: Drug Discovery

10:35 AM – 10:40 AM – Chair: Frederick Sachs

10:40 AM – 11:00 AM – Riccardo Rizzetto

Electrophysiology, Axxam – “ionChannel Optical High-content Microscope” for ligand-gated ion channels drug discovery.

11:00 AM – 11:20 AM – Frederick Sachs

Distinguished Professor, SUNY Department of Physiology and Biophysics – “Basic science wins: Therapy for muscular dystrophy from spider spit”

11:20 AM – 11:40AM – Tianbo Li

Scientist, Genentech – “High-throughput technologies in the new era of ion channel study and drug discovery”

11:40 AM – 12:40 PM – Lunch

12:40 AM – 1:00 PM – Poster Session

IC Session: Cardiac Safety and the CiPA Initiative

1:00 PM – 1:05 PM – Chair: Khaled Baraket

Assistant Professor, Faculty of Pharmacy, University of Alberta

1:05 PM – 1:25 PM – Khaled Baraket

Assistant Professor, Faculty of Pharmacy, University of Alberta – “Atomistic Computational Models To Predict Drug-mediated Cardiotoxicity”

1:25 PM – 1:45 PM – Wayne Giles

Professor, University of Calgary – “Electrophysiological Properties of Heart and Articular Joint Fibroblasts”

1:45 PM – 2:05 PM – Haoyu Zeng

Principal Scientist, Cellular Electrophysiology & Pharmacology, Safety & Exploratory Pharmacology Dept., SALAR Division, MERCK – “Distinct Ca2+ -Handling Properties in human Induced Pluripotent Stem Cell Derived-Cardiomyocytes Revealed by Exposure to Selective Ca2+-Modulating Agents”

2:05 PM – 2:25 PM – Najah Abi Gerges

Scientific Director, Anabios – “Adult human primary cardiomyocyte model for the simultaneous

prediction of drug-induced inotropic and proarrhythmia risk”

2:25 PM – 2:55 PM – Coffee Break & Posters

2:55 PM – 3:15 PM – Haiyang (David) Wei

Technical Director & Group Leader, Eurofins – “Validating Cardiac Ion Channels assays on the IonFlux System for the CiPA Paradigm”

3:15 PM – 3:35 PM – Glen Tibbits

Professor and Chair, Biomedical Physiology and Kinesiology, Simon Fraser University – “Use of hiPSCderived cardiomyocytes to study acquired and inherited arrhythmogenesis”

IC Session: Ion Channels as Pain Target

3:35 AM – 3:40 AM – Chair: Balwant Tuana

Professor, Department of Cellular and Molecular Medicine, University of Ottawa

3:40 PM – 4:00 PM – Gerald Zamponi

Professor and Senior Associate Dean, University of Calgary – “Deubiquitination of Cav3.2 T-type calcium channels as a new target for pain therapeutics”

4:00 PM – 4:20 PM – Yan Xu

Peter M. Winter Professor of Anesthesiology, Pharmacology & Chemical Biology, Physics & Astronomy, and Structural Biology, University of Pittsburgh – “NMR investigation of site-specific general anesthetic binding to the voltage-gated sodium channel NaChBac and the mechanisms of inhibition”

4:20 PM – 4:40 PM – Jie Zheng

Professor, University of California Davis – “Activation of nociceptive ion channel TRPV1”

4:40 PM – 5:00 – Closing Remarks – Dong Liang,

President and CEO, Aurora Biomed, Inc.