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Speaking Program and Schedule
Day1
7:30 AM – 8:30 AM – Registration
8:30 AM – 8: 40AM – Welcome & Opening Remarks: Sophia Liang, Aurora Biomed Inc.
Keynote Presentation
8:40 AM – 9:20AM – Brad Nelson
Director and Distinguished Scientist, Deeley Research Centre, BC Cancer Agency – “Customizing cancer immunotherapies to match the intrinsic tumor microenvironment”
PM Session: Immunotherapies and Cancer Treatment
9:20 AM – 9:25 AM – Chair: David Rabuka
Global Head of R&D, Chemical Biology, Catalent
9:25 AM – 9:45 AM – David Rabuka
Global Head of R&D, Chemical Biology, Catalent – “Developing Site-Specifically Modified Antibody Drug Conjugates (ADCs) Using a Chemoenzymatic Approach”
9:45 AM – 10:05 AM – Ester Falconer
Senior Scientist, Abcellera – “Deep screening of natural immune repertoires to generate candidate therapeutic antibodies against difficult targets”
10:05 AM – 10:25 AM – William Jia
Associate Professor, Brain Research Centre, University of British Columbia – “Oncolytic virotherapy: Ignite the fire of anti-tumor immunity in tumor microenvironment”
10:25 AM – 10:55 AM – Coffee Break & Posters
10:55 AM – 11:00 AM – Chair: Brad Nelson
Director and Distinguished Scientist, Deeley Research Centre, BC Cancer Agency
11:00 AM – 11:20 AM – Eric Holland
Senior VP and Director, Fred Hutchinson Cancer Research Center – “Using Mouse Models to Develop Immunotherapy Strategies for Gliomas”
11:20 AM – 11:40 AM – Christopher Triggle
Professor, Department of Pharmacology, Weill Cornell Medicine, Qatar – “Metformin: Does it have a role as an anti-cancer drug? If so it is all about the transporters”
11:40 AM – 12:00 PM – Heinrich Brinkmeier
Institute of Pathophysiology University Medicine Greifswald – “The plant alkaloid harmaline blocks the human voltage-gated sodium channel Nav1.7 expressed in CHO cells: a study using automated patch clamp”
Novel Perspective of Ion Channels in Precision Medicine
12:00 PM – 12:30 PM – Dong Liang
CEO, Aurora Biomed Inc – “Label-free Technologies of Ion Channels and Transporters: Rubidium Efflux Assay”
12:30 PM – 1:30 PM – Lunch
1:30 PM – 1:35 PM – Chair: Charlie Cohen
VP Biology, Xenon Pharmaceuticals
1:35 PM – 1:55 PM – Annarosa Arcangeli
Professor in Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Italy – “A novel perspective in personalized medicine: exploiting ion channels for cancer patients’stratification”
1:55 PM – 2:20 PM – Charlie Cohen
VP Biology, Xenon Pharmaceuticals – “A Novel Pain and Target Engagement Assay for hNaV1.7: efficacy in inflammatory and neuropathic pain models correlates with block of NaV1.7”
2:20 PM – 2:40 PM – JP Johnson
Senior Director, Cellular and Molecular Biology, Xenon Pharmaceuticals – “Selective targeting of NaV1.6 in an EIEE13 mouse model of epilepsy”
2:40 PM – 3:00 PM – Isabelle Deschenes
Professor of Medicine,, Case Western Reserve University – “Identification of New Long QT Syndrome Type 2 Modifier Genes Using a Physiological Genomics Approach”
3:00 PM – 3:20 PM – Saverio Gentile
Assistant Professor, Loyola University Chicago – “A Channelopathy called Cancer: From the understanding of K+ channel-dependent signaling to the design of novel precision cancer medicine”
3:20 PM – 3:55 PM – Coffee Break & Posters
IC Session: Ion Channels as Pain Target
3:55 PM – 4:00 PM – Chair: Chris Mathes
CSO Icagen
4:00 PM – 4:20 PM – Neil Castle
VP Research, Icagen – “Targeting Nav 1.9 for Development of New Pain Therapies”
4:20 PM – 4:40 PM – Bryan Moyer
Principal Scientist, Amgen – “NaV1.7 Inhibitory Peptide Conjugated to Carrier Antibody Increases Half-Life and Promotes Tissue Biodistribution to Nerve Elements”
4:40 PM – 5:00 PM – Vincenzo Carnevale
Research Associate Professor, Temple University – “Sensing the environment: a glimpse into the microscopic mechanisms of pain”
5:00 PM – 5:20 PM – Yan Xu
Peter M. Winter Professor of Anesthesiology, Pharmacology & Chemical Biology, Physics & Astronomy, and Structural Biology, University of Pittsburgh – “NMR investigation of site-specific general anesthetic binding to the voltage-gated sodium channel NaChBac and the mechanisms of inhibition”
5:20 PM – 5:40 PM – Jeffrey Herz
CEO, Algomedix – “Development of a Novel Class of TRPA1 Antagonists as Effective Analgesic Drugs in Multiple Models of Neuropathic Pain”
5:40 PM – 6:00 PM – Zhiyuan Li
Principal Investigator, Guangzhou Institutes Of Biomedicine And Health – “Overexpression of
thermo-TRPVs may promote the formation of the esophageal Squamous cell carcinoma”
Day2
8:00 AM – 8:30 AM – Registration
8:20 AM – 8: 25AM – Welcome & Opening Remarks: Aurora Biomed Inc
Keynote Presentation
8:25 AM – 9:05AM – Alfred George
Chair, Department of Pharmacology, Northwestern University – “Functional Annotation of Human Ion Channel Variants”
PM Session: Applications of NGS
9:05 AM – 9:10AM Chair: Alfred George
Department of Pharmacology, Northwestern University
9:10 AM – 9:30 AM – Ashleen Shadeo
Sector Manager, Health Genome BC – “Implementing Genomics in the Health Care System in Canada”
9:30 AM – 9:50 AM – Tao Chen
CEO, Paragon Genomics – “A Novel Amplicon-based NGS Target Enrichment Technology for Liquid Biopsies in Oncology”
9:50 AM – 10:10 AM – Amit Mahipal
Associate Professor, Mayo Clinic NGS – “How Molecular Testing has Changed Therapy Decisions in Colorectal Cancer”
10:10 AM – 10:30 AM – Gourab Bhattacharjee
Marketing Programs Manager, Oncology, Illumina – Immuno-Oncology Research Enabled Through Applied Advanced Genomic Techniques
10:30 AM – 10:50 AM – Coffee Break & Posters
Technologies and Technical Session
10:50 AM – 10:55 AM – Chair: Ali Yehia
VP IonFlux Product and Director of BioFlux Business Marketing, Fluxion
10:55 AM – 11:15 AM – Ali Yehia
VP IonFlux Product and Director of BioFlux Business Marketing, Fluxion – “Application of microfluidics to ion channel drug discovery and liquid biopsies for precise cancer diagnosis”
11:15 AM – 11:35 PM – Ander Lindqvist
Application Scientist, Sophion – “The effect of temperature on hERG channel pharmacology measured using the Qube automated patch clamp system”
11:35 AM – 11:55 PM – Daniel Beacham
Senior Staff Scientist, Molecular Probes Labelling and Detection, Thermo Fisher Scientific – “CultureOne Media Supplement Accelerates Functional NSC Maturation as Revealed with Improved Imaging Solutions”
11:55 PM – 12:20PM – Aneesh Karatt Vellatt
Senior Research Scientist, Iontas Ltd.- “KnotBodies: creating Ion channel blocking antibody by fusing knottins into peripheral CDR loops”
12:20 PM – 1:20 PM – Lunch
1:20 PM – 2:30 PM – PM Session Panel Discussion
– Break into Parallel Sessions-
-Precision Medicine Session-
PM Session: Liquid Biopsy and Molecular Diagnostics
2:35 PM – 2:40 PM – Chair: David Weitz
Professor, Mallinckrodt Professor of Physics and Applied Physics, Harvard University
2:40 PM – 3:00 PM – David Weitz
Professor, Mallinckrodt Professor of Physics and Applied Physics, Harvard University – “Droplet microfluidics for single cell studies”
3:00 PM – 3:20 PM – Werner Struss
Senior Research Scientist, Vancouver Prostate Centre – “Treatment outcomes and tumor loss-of -heterozygosity in germline DNA repair deficient prostate cancer”
3:20 PM – 3:40 PM – Miguel Alcaide
Research Associate, Simon Fraser University – “Novel ultrasensitive methods for the detection and quantification of tumor-derived genetic aberrations in the “liquid biopsy” era”
3:40 PM – 4:00 PM – Paul Li
Professor, Department of Molecular Biology and Biochemistry Simon Fraser University – “Microfluidic Technology for Liquid Biopsy in Precision Medicine”
4:00 PM – 4:25 PM – Coffee Break & Posters
PM Session: Lab-on-a-Chip and Biotechnology
4:25 PM – 4:30 PM – Chair: Paul August
VP, Icagen
4:30 PM – 4:50 PM – Paul August
VP , Icagen – “Patient derived stem cells as a strategy for the in vitro evaluation of muscular dystrophy therapies”
4:50 PM – 5:10 PM – Anthony Bahinski
Global Head, Safety Pharmacology, GlaxoSmithKline – “Human Organs on Chips: Opportunities and Challenges for Personalized Drug Development”
5:10 PM – 5:30 PM – Justin Ichida
Principal Investigator, University of Southern California Stem Cell – “Identification of therapeutic targets for ALS using chemical and genetic screens on patient-derived neural cultures”
– End of Parallel Session-
6:10 PM – 9:30 PM – Boat Cruise Banquet
-Ion Channel Session-
IC Session: Ion Channels and Transporters in Neuroscience
2:40 PM – 2:45 PM – Chair: Dandan Sun
Professor of Neurology, University of Pittsburgh
2:45 PM – 3:05 PM – Shan Ping Yu
Professor of Anesthesiology, Emory University School of Medicine – “Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice”
3:05 PM – 3:25 PM – Kris Kahle
Professor of Neurosurgery, Yale School of Medicine – “NKCC1-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus”
3:25 PM – 3:45 PM – Melanie A Woodin
Associate Professor, University of Toronto – “Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition”
3:45 PM – 4:05 PM – Sun Dandan
Professor of Neurology, University of Pittsburgh – “WNK-SPAK/OSR1 Signaling Pathway as a Novel Target for Ischemic Stroke Therapy ”
4:05 PM – 4:25 PM – Giuseppe Pignataro
Associate Professor in Pharmacology, Department of Neuroscience, School of Medicine, University of Naples – “Na+/Ca2+ exchangers in neurological diseases”
4:25 PM – 4:45 PM – Coffee Break & Posters
4:45 PM – 5:05 PM – Maria Barthmes
Application Specialist, Nanion – “Targeting transporters with HTS electrophysiology: The glutamate transporter EAAT3 on the SURFE2R 96SE”
5:05PM – 5:25 PM – Matt Fox
CEO, Pairnomix – “Comprehensive High Throughput Drug Screening in a Cellular Model of SCN8A Epilepsy ”
– End of Parallel Session-
6:10 PM – 9:30 PM – Boat Cruise Banquet
Day3
7:55 AM – 8:25 AM – Registration
IC Session: Ion channels as Disease Targets
8:20 AM – 8:30 AM – Opening Remarks
Chair: Yelena Bisharyan
Director of External Alliances , Tetragenetics
8:30 AM – 9:00 AM – Ted Clark
CSO Tetragenetics, Cornell University – “Antibodies Against Difficult to Express Ion Channel Targets”
9:00 AM – 9:20 AM – Robert Brenner
Associate Professor, University of Texas Health Science Center at San Antonio – “Membrane-Permeant SK Potassium Channel Antagonists are Potent Bronchorelaxants”
9:20 AM – 9:40 AM – Heike Wulff
Full Professor, Department of Pharmacology, University of California Davis – “Kv1.3 as a target
for inhibiting detrimental M1 microglia functions in ischemic stroke, Alzheimer’s and Parkinson’s disease”
9:40 AM – 10:00 AM – Brandon Brown
Associate Professor, University of Texas Health Science Center at San Antonio – “Membrane Permeant SK Potassium Channel Antagonists are Potent Bronchorelaxants”
10:00 AM – 10:35 AM – Coffee Break & Posters
IC Session: Drug Discovery
10:35 AM – 10:40 AM – Chair: Frederick Sachs
10:40 AM – 11:00 AM – Riccardo Rizzetto
Electrophysiology, Axxam – “ionChannel Optical High-content Microscope” for ligand-gated ion channels drug discovery.
11:00 AM – 11:20 AM – Frederick Sachs
Distinguished Professor, SUNY Department of Physiology and Biophysics – “Basic science wins: Therapy for muscular dystrophy from spider spit”
11:20 AM – 11:40AM – Tianbo Li
Scientist, Genentech – “High-throughput technologies in the new era of ion channel study and drug discovery”
11:40 AM – 12:40 PM – Lunch
12:40 AM – 1:00 PM – Poster Session
IC Session: Cardiac Safety and the CiPA Initiative
1:00 PM – 1:05 PM – Chair: Khaled Baraket
Assistant Professor, Faculty of Pharmacy, University of Alberta
1:05 PM – 1:25 PM – Khaled Baraket
Assistant Professor, Faculty of Pharmacy, University of Alberta – “Atomistic Computational Models To Predict Drug-mediated Cardiotoxicity”
1:25 PM – 1:45 PM – Wayne Giles
Professor, University of Calgary – “Electrophysiological Properties of Heart and Articular Joint Fibroblasts”
1:45 PM – 2:05 PM – Haoyu Zeng
Principal Scientist, Cellular Electrophysiology & Pharmacology, Safety & Exploratory Pharmacology Dept., SALAR Division, MERCK – “Distinct Ca2+ -Handling Properties in human Induced Pluripotent Stem Cell Derived-Cardiomyocytes Revealed by Exposure to Selective Ca2+-Modulating Agents”
2:05 PM – 2:25 PM – Najah Abi Gerges
Scientific Director, Anabios – “Adult human primary cardiomyocyte model for the simultaneous
prediction of drug-induced inotropic and proarrhythmia risk”
2:25 PM – 2:55 PM – Coffee Break & Posters
2:55 PM – 3:15 PM – Haiyang (David) Wei
Technical Director & Group Leader, Eurofins – “Validating Cardiac Ion Channels assays on the IonFlux System for the CiPA Paradigm”
3:15 PM – 3:35 PM – Glen Tibbits
Professor and Chair, Biomedical Physiology and Kinesiology, Simon Fraser University – “Use of hiPSCderived cardiomyocytes to study acquired and inherited arrhythmogenesis”
IC Session: Ion Channels as Pain Target
3:35 AM – 3:40 AM – Chair: Balwant Tuana
Professor, Department of Cellular and Molecular Medicine, University of Ottawa
3:40 PM – 4:00 PM – Gerald Zamponi
Professor and Senior Associate Dean, University of Calgary – “Deubiquitination of Cav3.2 T-type calcium channels as a new target for pain therapeutics”
4:00 PM – 4:20 PM – Yan Xu
Peter M. Winter Professor of Anesthesiology, Pharmacology & Chemical Biology, Physics & Astronomy, and Structural Biology, University of Pittsburgh – “NMR investigation of site-specific general anesthetic binding to the voltage-gated sodium channel NaChBac and the mechanisms of inhibition”
4:20 PM – 4:40 PM – Jie Zheng
Professor, University of California Davis – “Activation of nociceptive ion channel TRPV1”
4:40 PM – 5:00 – Closing Remarks – Dong Liang,
President and CEO, Aurora Biomed, Inc.
Speakers
*Listed in no particular order