Ion channels & transporters are important therapeutic targets in the drug development pipeline and drug safety evaluation. These drug targets are critically important for a range of physiological conditions and disorders.

It has been also well-documented that ion channels and transporters are specific targets for numerous toxins. A considerable number of toxins are known as Neurotoxins and are mainly secrets by various venomous species targeting ion channels of the neuronal network. Some are also extracted from other natural sources. Ion channel-targeted toxins are promising drug candidates and also leading molecules for the treatment of several disorders.

Aside from that every year many drug candidates or under-application drugs are withdrawn from the market due to cardiac-related adverse effects. Interestingly it has been shown that many adverse effects are due to the blockage in the human ether-a-go-go (hERG) ion channel, which delays repolarization of the cardiac action potential and can eventually result in a potentially fatal arrhythmia known as Torsades de Pointes (TdP). In particular, it has been found that compounds often exhibit cross-reactivity between closely related family members of their targets. ​

Aurora Biomed provides testing of your compound of interest or toxins against various ion channels and transporters using manual patch clamp (the gold standard method of electrophysiology) to the high throughput automated ion channel reader (ICR) technology. Our Scientists help you to determine the right assay format and platform for your specific requirements and also help you to run your experiments safely and fast through your data interpretation. We help you to find solutions for your ion channel/transporter research that meet your needs and also provide comprehensive in vitro assessment for compound safety profiles in the early-phase discovery process.